The relevance of pre-motor symptoms in Parkinson's disease.
Identifieur interne : 000492 ( Main/Exploration ); précédent : 000491; suivant : 000493The relevance of pre-motor symptoms in Parkinson's disease.
Auteurs : Naomi Visanji [Canada] ; Connie MarrasSource :
- Expert review of neurotherapeutics [ 1744-8360 ] ; 2015.
English descriptors
- KwdEn :
- Autonomic Nervous System Diseases (diagnosis), Autonomic Nervous System Diseases (etiology), Constipation (diagnosis), Constipation (etiology), Early Diagnosis, Humans, Mood Disorders (diagnosis), Mood Disorders (etiology), Olfaction Disorders (diagnosis), Olfaction Disorders (etiology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Sleep Wake Disorders (diagnosis), Sleep Wake Disorders (etiology).
- MESH :
- diagnosis : Autonomic Nervous System Diseases, Constipation, Mood Disorders, Olfaction Disorders, Parkinson Disease, Sleep Wake Disorders.
- etiology : Autonomic Nervous System Diseases, Constipation, Mood Disorders, Olfaction Disorders, Sleep Wake Disorders.
- physiopathology : Parkinson Disease.
- Early Diagnosis, Humans.
Abstract
Parkinson's disease (PD) has a wide range of non-motor symptoms including; constipation, sleep disturbance, deficits in vision and olfaction, mood disorders and cardiac autonomic dysfunction. Several of these non-motor symptoms can manifest prior to the onset of motor symptoms. Recognizing these pre-motor symptoms may enable early diagnosis of PD. Currently, no single pre-motor symptom is able to predict the development of PD with 100% sensitivity or specificity. Ongoing studies in several independent at-risk cohorts should reveal the potential of combinations of pre-motor symptoms and multi-stage screening strategies to identify individuals at increased risk of PD. PD progression may be governed by a prion-like spread of a-syn throughout the nervous system. Identifying individuals at the earliest stage will likely be critical to preventing the pathological progression of PD, highlighting the relevance of pre-motor symptoms in the future treatment of the disease.
DOI: 10.1586/14737175.2015.1083423
PubMed: 26416397
Affiliations:
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Le document en format XML
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Several of these non-motor symptoms can manifest prior to the onset of motor symptoms. Recognizing these pre-motor symptoms may enable early diagnosis of PD. Currently, no single pre-motor symptom is able to predict the development of PD with 100% sensitivity or specificity. Ongoing studies in several independent at-risk cohorts should reveal the potential of combinations of pre-motor symptoms and multi-stage screening strategies to identify individuals at increased risk of PD. PD progression may be governed by a prion-like spread of a-syn throughout the nervous system. Identifying individuals at the earliest stage will likely be critical to preventing the pathological progression of PD, highlighting the relevance of pre-motor symptoms in the future treatment of the disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name></noCountry><country name="Canada"><noRegion><name sortKey="Visanji, Naomi" sort="Visanji, Naomi" uniqKey="Visanji N" first="Naomi" last="Visanji">Naomi Visanji</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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